Solubility determination from clear points upon solvent addition
Reus, Marloes A. and Van Der Heijden, Antoine E. D. M. and Ter Horst, Joop H. (2015) Solubility determination from clear points upon solvent addition. Organic Process Research and Development, 19 (8). pp. 1004-1011. ISSN 1083-6160 (https://doi.org/10.1021/acs.oprd.5b00156)
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Abstract
A method is described for determining the solubility of multicomponent crystalline compounds from clear points upon sample dilution at a constant temperature. Clear points are established by continuously adding a solvent mixture to a suspension of known composition until a clear solution appears. For validation, this solvent addition method is compared to the traditional equilibrium concentration method at constant temperature and the more recent temperature variation method with which clear point temperatures are determined upon increasing the sample temperature. Solubility data of binary systems (1 solute, 1 solvent) measured using the solvent addition method are obtained relatively quickly compared to the equilibrium concentration method. These solubility data are consistent with those of the temperature variation and the equilibrium concentration method. For the temperature variation method, the results are dependent on the heating rate. Likewise, for the solvent addition method, they are dependent on the addition rate. Additionally, for ternary systems involving antisolvent or cocrystals, solubilities are determined at a constant temperature using the solvent addition method. The use of the solvent addition method is especially valuable in the case of solvent mixtures and other complex multicomponent systems, in which the temperature variation method cannot be applied easily.
ORCID iDs
Reus, Marloes A., Van Der Heijden, Antoine E. D. M. and Ter Horst, Joop H. ORCID: https://orcid.org/0000-0003-0118-2160;-
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Item type: Article ID code: 54224 Dates: DateEvent3 August 2015Published3 August 2015AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
University of Strathclyde > University of StrathclydeDepositing user: Pure Administrator Date deposited: 08 Sep 2015 15:28 Last modified: 11 Nov 2024 11:11 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/54224