MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Kalafatovic, Daniela and Nobis, Max and Javid, Nadeem and Frederix, Pim W. J. M. and Anderson, Kurt I. and Saunders, Brian R. and Ulijn, Rein V. (2015) MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Science, 3 (2). pp. 246-249. ISSN 2047-4830

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    Abstract

    Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.