Polymorphism of a polymer pre-cursor : metastable glycolide polymorph recovered via large scale high-pressure experiments

Hutchison, Ian B. and Delori, Amit and Wang, Xiao and Kamenev, Konstantin V. and Urquhart, Andrew J. and Oswald, Iain D.H. (2015) Polymorphism of a polymer pre-cursor : metastable glycolide polymorph recovered via large scale high-pressure experiments. CrystEngComm, 17 (8). 1778 - 1782. ISSN 1466-8033

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    Abstract

    A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

    Creators(s): Hutchison, Ian B., Delori, Amit, Wang, Xiao, Kamenev, Konstantin V., Urquhart, Andrew J. and Oswald, Iain D.H. ORCID logoORCID: https://orcid.org/0000-0003-4339-9392;
    Item type:Article
    ID code:53762
    Keywords:glycolide, polyglycolic acid, crystallisation, Chemistry, Pharmacy and materia medica, Materials Science(all), Chemistry(all), Condensed Matter Physics
    Subjects:Science > Chemistry
    Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
    Depositing user: Pure Administrator
    Date deposited:14 Jul 2015 15:29
    Last modified:22 Feb 2020 19:46
    URI:https://strathprints.strath.ac.uk/id/eprint/53762
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