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Open Access research that is better understanding work in the global economy...

Strathprints makes available scholarly Open Access content by researchers in the Department of Work, Employment & Organisation based within Strathclyde Business School.

Better understanding the nature of work and labour within the globalised political economy is a focus of the 'Work, Labour & Globalisation Research Group'. This involves researching the effects of new forms of labour, its transnational character and the gendered aspects of contemporary migration. A Scottish perspective is provided by the Scottish Centre for Employment Research (SCER). But the research specialisms of the Department of Work, Employment & Organisation go beyond this to also include front-line service work, leadership, the implications of new technologies at work, regulation of employment relations and workplace innovation.

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From structure to function : mitochondrial morphology, motion and shaping in vascular smooth muscle

McCarron, J.G. and Wilson, C. and Sandison, M.E. and Olson, M.L. and Girkin, J.M. and Saunter, C. and Chalmers, S. (2013) From structure to function : mitochondrial morphology, motion and shaping in vascular smooth muscle. Journal of Vascular Research, 50 (5). pp. 357-371. ISSN 1018-1172

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Abstract

The diversity of mitochondrial arrangements, which arise from the organelle being static or moving, or fusing and dividing in a dynamically reshaping network, is only beginning to be appreciated. While significant progress has been made in understanding the proteins that reorganise mitochondria, the physiological significance of the various arrangements is poorly understood. The lack of understanding may occur partly because mitochondrial morphology is studied most often in cultured cells. The simple anatomy of cultured cells presents an attractive model for visualizing mitochondrial behaviour but contrasts with the complexity of native cells in which elaborate mitochondrial movements and morphologies may not occur. Mitochondrial changes may take place in native cells (in response to stress and proliferation), but over a slow time-course and the cellular function contributed is unclear. To determine the role mitochondrial arrangements play in cell function, a crucial first step is characterisation of the interactions among mitochondrial components. Three aspects of mitochondrial behaviour are described in this review: (1) morphology, (2) motion and (3) rapid shape changes. The proposed physiological roles to which various mitochondrial arrangements contribute and difficulties in interpreting some of the physiological conclusions are also outlined.

Item type: Article
ID code: 53734
Keywords: cells, cultured, dyneins, humans, kinesin, microtubules, mitochondria, mitochondrial dynamics, mitochondrial membranes, mitochondrial proteins, movement , muscle, smooth, vascular, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Biomedical Engineering
Depositing user: Pure Administrator
Date deposited: 14 Jul 2015 08:30
Last modified: 03 Jan 2019 14:20
URI: https://strathprints.strath.ac.uk/id/eprint/53734
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