Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics

Cunha Matos, C.A. and Millington, O.M. and Wark, A. W. and Zagnoni, M. (2014) Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics. In: 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014). CBM Society, San Diego, CA., pp. 968-970. ISBN 9781634396974

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Abstract

We present an interdisciplinary approach that allows for the evaluation of nanoparticle cytotoxicity at the single-cell level. By combining single-cell microfluidics with nanoparticle chemistry, real-time and high-throughput multimodal imaging of cellular interactions with functionalised gold nanorods was successfully achieved. The integration of such techniques into tools for high-resolution cell monitoring and drug screening has, to the best of our knowledge, not been reported.