Through-space transfer of chiral information mediated by a plasmonic nanomaterial
Ostovar pour, Saeideh and Rocks, Louise and Faulds, Karen and Graham, Duncan and Parchaňský, Václav and Bouř, Petr and Blanch, Ewan W. (2015) Through-space transfer of chiral information mediated by a plasmonic nanomaterial. Nature Chemistry, 7 (7). 591–596. ISSN 1755-4330 (https://doi.org/10.1038/nchem.2280)
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Abstract
The ability to detect chirality gives stereochemically attuned nanosensors the potential to revolutionise the study of biomolecular processes. Such devices may structurally characterise the mechanisms of protein-ligand binding, the intermediates of amyloidogenic diseases and the effects of phosphorylation and glycosylation. We demonstrate that single nanoparticle plasmonic reporters, or nanotags, can enable a stereochemical response to be transmitted from a chiral analyte to an achiral benzotriazole dye molecule in the vicinity of a plasmon resonance from an achiral metallic nanostructure. The transfer of chirality was verified by the measurement of mirror image surface enhanced resonance Raman optical activity spectra for the two enantiomers of each of ribose and tryptophan. Computational modelling confirms these observations and reveals the novel chirality transfer mechanism responsible. This is the first report of colloidal metal nanoparticles in the form of single plasmonic substrates displaying an intrinsic chiral sensitivity once attached to a chiral molecule.
ORCID iDs
Ostovar pour, Saeideh, Rocks, Louise, Faulds, Karen ORCID: https://orcid.org/0000-0002-5567-7399, Graham, Duncan ORCID: https://orcid.org/0000-0002-6079-2105, Parchaňský, Václav, Bouř, Petr and Blanch, Ewan W.;-
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Item type: Article ID code: 53029 Dates: DateEvent31 July 2015Published15 June 2015Published Online12 May 2015AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 15 May 2015 10:30 Last modified: 16 Dec 2024 07:29 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/53029