Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy

Martin, Tamara and Hortigon-Vinagre, Maria and Findlay, Jane and Elliott, Christina and Currie, Susan and Baillie, George (2014) Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy. FEBS Open Bio, 4. pp. 923-927. ISSN 2211-5463 (https://doi.org/10.1016/j.fob.2014.10.011)

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Abstract

Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of the HSP20–phosphodiesterase 4D (PDE4D) complex results in attenuation of action potential prolongation and protection against adverse cardiac remodelling. The later was evidenced by improved contractility, decreased heart weight to body weight ratio, and reduced interstitial and perivascular fibrosis. This study demonstrates that disruption of the specific HSP20–PDE4D interaction leads to attenuation of pathological cardiac remodelling.

ORCID iDs

Martin, Tamara, Hortigon-Vinagre, Maria, Findlay, Jane, Elliott, Christina, Currie, Susan ORCID logoORCID: https://orcid.org/0000-0002-4237-4428 and Baillie, George;
CORE (COnnecting REpositories)