Anti-cancer efficacy of intravenously administered tumor-targeted vesicles entrapping tocotrienol
Fu, Ju Yen and Dufès, Christine (2015) Anti-cancer efficacy of intravenously administered tumor-targeted vesicles entrapping tocotrienol. Pharmaceutical Nanotechnology, 2 (4). pp. 172-181. ISSN 2211-7385 (https://doi.org/10.2174/2211738503666150119231232)
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Abstract
Despite its potent in vitro anti-cancer activity, the vitamin E extract tocotrienol has its therapeutic potential hampered by its poor bioavailability and by its inability to reach tumors in a specific way after intravenous administration. One possibility to overcome this issue would be to entrap tocotrienol within vesicles bearing transferrin, whose receptors are present in abundance on many cancer cell types. In this study, we demonstrated that the systemic administration of tocotrienol entrapped within transferrin-bearing vesicles led to tumor suppression of 20% of A431 epidermoid carcinoma tumors and 50% of B16 - F10 melanoma tumors at the end of the treatment. The survival of animals treated with these vesicles was improved by more than 20 days in comparison with the controls, for the two cancer models tested. Animals did not show any secondary effects following administration of the treatment. The entrapment of tocotrienol within transferrin-bearing vesicles is therefore a promising therapeutic strategy, which could result in tumor suppression after systemic administration of this delivery system.
ORCID iDs
Fu, Ju Yen and Dufès, Christine ORCID: https://orcid.org/0000-0002-7963-6364;-
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Item type: Article ID code: 51976 Dates: DateEvent15 May 2015Published19 January 2015AcceptedNotes: The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/2211738503666150119231232 Subjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 27 Feb 2015 10:49 Last modified: 11 Nov 2024 10:57 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/51976