Carbon nanotubes for stabilization of nanostructured lipid particles
Gaunt, Nicholas P. and Patil-Sen, Yogita and Baker, Matthew J. and Kulkarni, Chandrashekhar V. (2015) Carbon nanotubes for stabilization of nanostructured lipid particles. Nanoscale, 7 (3). pp. 1090-1095. ISSN 2040-3372 (https://doi.org/10.1039/c4nr05593d)
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Abstract
Carbon nanotubes (CNTs) are increasingly studied for innovative biotechnological applications particularly where they are combined with essential biological materials like lipids. Lipids have been used earlier for enhancing the dispersibility of CNTs in aqueous solutions. Here we report a novel application of CNTs for stabilization of internally self-assembled nanostructured lipid particles of 2-5 μm size. Single-walled (pristine) as well as -OH and -COOH functionalized multi-walled CNTs were employed to produce nanostructured emulsions which stayed stable for months and could be re-dispersed after complete dehydration. Concentrations of CNTs employed for stabilization were very low; moreover CNTs were well-decorated with lipid molecules. These features contribute towards reducing their toxicity and improving biocompatibility for biomedical and pharmaceutical applications. Our approach paves the way for future development of combination therapies employing both CNTs and nanostructured lipid self-assembly together as carriers of different drugs.
ORCID iDs
Gaunt, Nicholas P., Patil-Sen, Yogita, Baker, Matthew J. ORCID: https://orcid.org/0000-0003-2362-8581 and Kulkarni, Chandrashekhar V.;-
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Item type: Article ID code: 51683 Dates: DateEvent21 January 2015Published20 November 2014Published Online16 November 2014AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
University of Strathclyde > University of StrathclydeDepositing user: Pure Administrator Date deposited: 16 Feb 2015 16:25 Last modified: 03 Nov 2024 01:52 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/51683