The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels

Busby, Grahame and Riches, Philip and Grant, Mary and MacKay, Simon (2013) The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels. International Journal of Artificial Organs, 36 (8). p. 567. O106. ISSN 0391-3988 (https://doi.org/10.5301/ijao.5000244)

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Abstract

Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.

ORCID iDs

Busby, Grahame, Riches, Philip ORCID logoORCID: https://orcid.org/0000-0002-7708-4607, Grant, Mary ORCID logoORCID: https://orcid.org/0000-0002-7712-404X and MacKay, Simon ORCID logoORCID: https://orcid.org/0000-0001-8000-6557;
CORE (COnnecting REpositories)