Tuneable Fmoc–Phe–(4-X)–Phe–NH2 nanostructures by variable electronic substitution

Pappas, Charalampos G and Abul-Haija, Yousef M and Flack, Angela and Frederix, Pim W J M and Ulijn, Rein V (2014) Tuneable Fmoc–Phe–(4-X)–Phe–NH2 nanostructures by variable electronic substitution. Chemical Communications, 50 (73). pp. 10630-10633. ISSN 1359-7345

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    Abstract

    Supramolecular structures were produced by in situ enzymatic condensation of Fmoc-Phe-(4-X), where X denotes electron withdrawing or donating groups, with Phe-NH2. The relative contribution of π-stacking and H-bonding interactions can be regulated by the nature of X, resulting in tuneable nanoscale morphologies.