Swinhoeiamide A, a new highly active calyculin derivative from the marine sponge Theonella swinhoei

Edrada-Ebel, Ruangelie and Ebel, Rainer and Supriyono, Agus and Wray, Victor and Schupp, Peter and Steube, Klaus and van Soest, Rob and Proksch, Peter (2002) Swinhoeiamide A, a new highly active calyculin derivative from the marine sponge Theonella swinhoei. Journal of Natural Products, 65 (8). pp. 1168-1172. ISSN 0163-3864

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Abstract

Analysis of the Papua New Guinean sponge Theonella swinhoei afforded a new calyculinamide-related congener for which we propose the name swinhoeiamide A (1). The structure of the new compound was unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, HMBC) and mass spectrometric (FABMS) data. Swinhoeiamide A exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated in an artificial diet offered to the larvae in a chronic feeding bioassay (ED(50) 2.11 ppm, LD(50) 2.98 ppm). Furthermore, it was found to be fungicidal against Candida albicans and Aspergillus fumigatus (MIC 1.2 and 1.0 microg/mL, respectively).

  • Item type:Article
    ID code:48481
    Dates:
    Date
    Event
    August 2002
    Published
    Keywords:animals, antifungal agents, aspergillus fumigatus, candida albicans, chromatography, high pressure liquid, feeding behavior, insecticides, larva, molecular structure, organophosphates, oxazoles, Papua New Guinea, porifera, spectrophotometry, ultraviolet, spodoptera, fungal spores, Chemistry, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
    Subjects:Science > Chemistry
    Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:10 Jun 2014 10:07
    Last modified:07 May 2021 03:59
    URI:https://strathprints.strath.ac.uk/id/eprint/48481
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