Swinhoeiamide A, a new highly active calyculin derivative from the marine sponge Theonella swinhoei

Edrada-Ebel, Ruangelie and Ebel, Rainer and Supriyono, Agus and Wray, Victor and Schupp, Peter and Steube, Klaus and van Soest, Rob and Proksch, Peter (2002) Swinhoeiamide A, a new highly active calyculin derivative from the marine sponge Theonella swinhoei. Journal of Natural Products, 65 (8). pp. 1168-1172. ISSN 0163-3864

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Abstract

Analysis of the Papua New Guinean sponge Theonella swinhoei afforded a new calyculinamide-related congener for which we propose the name swinhoeiamide A (1). The structure of the new compound was unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, HMBC) and mass spectrometric (FABMS) data. Swinhoeiamide A exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated in an artificial diet offered to the larvae in a chronic feeding bioassay (ED(50) 2.11 ppm, LD(50) 2.98 ppm). Furthermore, it was found to be fungicidal against Candida albicans and Aspergillus fumigatus (MIC 1.2 and 1.0 microg/mL, respectively).

Creators(s): Edrada-Ebel, Ruangelie, Ebel, Rainer, Supriyono, Agus, Wray, Victor, Schupp, Peter, Steube, Klaus, van Soest, Rob and Proksch, Peter;
Item type:Article
ID code:48481
Keywords:animals, antifungal agents, aspergillus fumigatus, candida albicans, chromatography, high pressure liquid, feeding behavior, insecticides, larva, molecular structure, organophosphates, oxazoles, Papua New Guinea, porifera, spectrophotometry, ultraviolet, spodoptera, fungal spores, Chemistry, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects:Science > Chemistry
Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:10 Jun 2014 10:07
Last modified:02 Sep 2020 03:25
URI:https://strathprints.strath.ac.uk/id/eprint/48481
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