Continuous infusion of vancomycin in neonates

Patel, Anisa D. and Anand, Dhullipala and Lucas, Carol and Thomson, Alison (2013) Continuous infusion of vancomycin in neonates. Archives of Disease in Childhood, 98 (6). pp. 478-479. ISSN 0003-9888 (

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A one year, retrospective audit of intermittent vancomycin therapy within the Neonatal Unit at the Royal Hospital for Sick Children, Glasgow, found that only 33% of 984 vancomycin trough levels were within the British National Formulary for children (BNFc) target range of 10–15 mg/l and 25% were <10 mg/l. A detailed, prospective review of 20 courses (15 patients) over one month, while using the same dosing guidelines, highlighted that only 23 of 50 concentration measurements (46%) were within the target range and 20% were <10 mg/l, even though the initial doses used (table 1) were higher than those recommended by the BNFc. Dose adjustments were common and up to 80 mg/kg/day was often required for older infants. Appropriate interpretation of concentration results was compromised …