Investigation of factors affecting isolation of needle-shaped particles in a vacuum-agitated filter drier through non-invasive measurements by Raman spectrometry

Hamilton, Peter and Littlejohn, David and Nordon, Alison and Sefcik, Jan and Slavin, Paul and Andrews, John and Dallin, Paul (2013) Investigation of factors affecting isolation of needle-shaped particles in a vacuum-agitated filter drier through non-invasive measurements by Raman spectrometry. Chemical Engineering Science, 101. pp. 878-885. ISSN 0009-2509 (https://doi.org/10.1016/j.ces.2013.05.035)

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Abstract

The effects of pressure filtration and vacuum agitated drying on cellobiose octaacetate (COA) particles in methanol slurries were studied by making Raman measurements through the glass wall at the side of a filter drier beneath the oil jacket. The change in intensity of methanol peaks in the spectra allowed the removal of the solvent from the particle bed to be monitored. Also, drying curves for COA generated from the Raman measurements gave an indication of the changing physical status of the particle bed during continuous or intermittent agitation. The intensity of the Raman signal for COA depended on the bulk density of the particle bed, which changed due to aggregation and attrition that occurred during solvent removal and particle motion induced by agitation during vacuum drying. Loss on drying (LOD) measurements of samples removed at the end of the pressure filtration and vacuum agitated drying stages established the degree of wetness and confirmed the end point of drying (<0.5% w/w solvent), respectively. Dynamic image analysis confirmed that minimum attrition of COA was achieved when (a) the majority of the methanol was removed during pressure filtration at 0.5bar N2 and (b) intermittent agitation was applied during the vacuum drying stage.

ORCID iDs

Littlejohn, David ORCID: https://orcid.org/0000-0002-1555-9427

Nordon, Alison ORCID: https://orcid.org/0000-0001-6553-8993

Sefcik, Jan ORCID: https://orcid.org/0000-0002-7181-5122

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  Item type:	Article
  ID code:	48378
  Dates:	Date Event 1 September 2013 Published 27 May 2013 Published Online
  Notes:	Notice: This is the author's version of a work that was accepted for publication in Chemical Engineering Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Engineering Science, [101, 20 Sept., (2013)] DOI: 10.1016/j.ces.2013.05.035
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC) Faculty of Engineering > Chemical and Process Engineering
  Depositing user:	Pure Administrator
  Date deposited:	02 Jun 2014 10:05
  Last modified:	12 Dec 2024 02:57
  Related URLs:	Scopus publication Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/48378