The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein
Johnson, Deborah-Ann and Smith, Kevin D. (2006) The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein. Biomedical Chromatography, 20. pp. 551-560. ISSN 0269-3879
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One of the most ubiquitous plasma proteins, -1-acid glycoprotein (AGP), has a high affinity, low capacity binding for basic drugs positively charged at physiological pH. Moreover, as an acute phase protein its level is increased in various disease states in a manner that is likely to influence the free plasma level of a drug, the ability to attain minimum effective concentration and overall in vivo effectiveness. AGP is a glycoprotein known to display disease specific changes in glycosylation and although this secondary modification is not directly involved in drug binding, it may influence the conformation of the binding site. Binding studies reveal that -1-acid glycoprotein bind mainly to the tuberculosis drugs: rifampicin; isoniazid; pyrazinamide; p-aminosalicylic acid; capreomycin; ethionamide; levofloxacin and ofloxacin out with the therapeutic plasma range tested. These results are however still considered significant as not only are -1-acid glycoprotein levels increased during the acute phase response but specific -1-acid glycoprotein from tuberculosis samples are subject to glycosylation changes which can increase the binding affinity and cause binding to occur at the therapeutic concentration.
| Creators(s): | Johnson, Deborah-Ann and Smith, Kevin D.; | Item type: | Article |
|---|---|
| ID code: | 4783 |
| Keywords: | bioscience, tuberculosis, pharmacology, chromatography, physiology, binding studies, fluorimetry, Public health. Hygiene. Preventive Medicine, Physiology, Microbiology, Biochemistry, Drug Discovery, Molecular Biology, Analytical Chemistry, Pharmacology, Clinical Biochemistry |
| Subjects: | Medicine > Public aspects of medicine > Public health. Hygiene. Preventive Medicine Science > Physiology Science > Microbiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Strathprints Administrator |
| Date deposited: | 14 Nov 2007 |
| Last modified: | 21 May 2020 00:21 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/4783 |
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