3D optical imaging of multiple SERS nanotags in cells
McAughtrie, Sarah and Lau, Katherine and Faulds, Karen and Graham, Duncan (2013) 3D optical imaging of multiple SERS nanotags in cells. Chemical Science, 4 (9). pp. 3566-3572. ISSN 2041-6539 (https://doi.org/10.1039/c3sc51437d)
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Recent studies have clearly demonstrated that Raman and surface enhanced Raman scattering (SERS) spectroscopies are information rich, non-destructive techniques for the monitoring of subtle intracellular changes. However, despite the demonstrated and sophisticated applications of these techniques in cell studies there still remains a lack of accompanying 3D images. Herein we demonstrate for the first time combined 3D Raman and SERS imaging for the simultaneous confirmation of the cellular inclusion and multiple component detection of SERS nanotags. We also report on the 3D elucidation of the cell nuclei by multivariate analysis methods. Imaging in 3D will be critical to understanding architectural changes between diseased and healthy cells, and tissues. It will also provide non-destructive definitive proof of cellular uptake whilst simultaneously confirming targeting of SERS nanotags to their intended destinations.
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Item type: Article ID code: 47468 Dates: DateEvent1 September 2013Published10 July 2013Published OnlineSubjects: Science > Chemistry Department: University of Strathclyde > University of Strathclyde
Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 11 Apr 2014 13:07 Last modified: 25 May 2024 15:06 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/47468