Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid
Ali, Saqib and Igoli, John and Clements, Carol and Semaan, Dima and Almazeb, Muhammad and Rashid, Mamoon-Ur and Shah, Syed Qaisar and Ferro, Valerie and Gray, Alexander and Khan, M Rafiullah (2013) Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid. Bangladesh Journal of Pharmacology, 8 (3). pp. 336-342. (https://doi.org/10.3329/bjp.v8i3.13888)
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Abstract
Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were isolated from the active fractions of these species for the first time. The antidiabetic activity was determined against Protein Tyrosine Phosphatase 1B (PTP 1B), a negative insulin regulator while the antimicrobial activity was performed against four bacterial strains: Mycobacterium marinum ATCC BAA535, sporadic Methicillin Resistant Staphylococcus aureus (SMRSA), endemic Methicillin Resistant Staphylococcus aureus (EMRSA) and Escherichia coli ATCC.8739 at different concentrations. Amongst the isolated compounds 8-oxo-berberine was found to be the most active antidiabetic (29 % of the positive control) while jatrorrhizine was the most active and selective antimicrobial against SMRSA and EMRSA (-1.2 % of the DMSO (D) control).
ORCID iDs
Ali, Saqib, Igoli, John, Clements, Carol, Semaan, Dima, Almazeb, Muhammad, Rashid, Mamoon-Ur, Shah, Syed Qaisar, Ferro, Valerie ORCID: https://orcid.org/0000-0003-1967-3603, Gray, Alexander and Khan, M Rafiullah;-
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Item type: Article ID code: 46417 Dates: DateEvent2013Published1 August 2013Published OnlineSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 07 Jan 2014 11:43 Last modified: 03 Sep 2024 00:49 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/46417