Local detection of enzymatic ion generation with polycrystalline silicon interdigitated electrodes and its application to biosensing
de la Rica, Roberto and Baldi, Antonio and Fernández-Sánchez, César (2007) Local detection of enzymatic ion generation with polycrystalline silicon interdigitated electrodes and its application to biosensing. Applied Physics Letters, 90. 074102. ISSN 0003-6951 (https://doi.org/10.1063/1.2472718)
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Abstract
Chips containing polycrystalline silicon interdigitated electrodes are modified with the enzyme urease. The sensors are able to detect changes in the resitivity of the solution near their surface, where the enzymatic reaction generates charged species. The electrodes are also grafted with an antigen and queried with different amounts of urease labeled antibody. The response of the modified electrodes is proportional to the amount of enzyme attached to the surface by the biorecognition event, thus validating the assay for biosensing applications.
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Item type: Article ID code: 45756 Dates: DateEvent12 February 2007Published31 January 2007AcceptedSubjects: Science > Physics Department: Faculty of Science > Physics Depositing user: Pure Administrator Date deposited: 08 Nov 2013 09:42 Last modified: 15 Sep 2024 00:43 URI: https://strathprints.strath.ac.uk/id/eprint/45756