Biocatalytically triggered co-assembly of two-component core/shell nanofibers

Abul-Haija, Yousef M and Roy, Sangita and Frederix, Pim W J M and Javid, Nadeem and Jayawarna, Vineetha and Ulijn, Rein V (2013) Biocatalytically triggered co-assembly of two-component core/shell nanofibers. Small.

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    Abstract

    For the development of applications and novel uses for peptide nanostructures, robust routes for their surface functionalization, that ideally do not interfere with their self-assembly properties, are required. Many existing methods rely on covalent functionalization, where building blocks are appended with functional groups, either pre- or post-assembly. A facile supramolecular approach is demonstrated for the formation of functionalized nanofibers by combining the advantages of biocatalytic self-assembly and surfactant/gelator co-assembly. This is achieved by enzymatically triggered reconfiguration of free flowing micellar aggregates of pre-gelators and functional surfactants to form nanofibers that incorporate and display the surfactants' functionality at the surface. Furthermore, by varying enzyme concentration, the gel stiffness and supramolecular organization of building blocks can be varied.

    Author(s):Abul-Haija, Yousef M ORCID logoORCID: https://orcid.org/0000-0002-0357-0653, Roy, Sangita, Frederix, Pim W J M, Javid, Nadeem, Jayawarna, Vineetha ORCID logoORCID: https://orcid.org/0000-0002-2936-6634 and Ulijn, Rein V ORCID logoORCID: https://orcid.org/0000-0001-7974-3779
    Item type:Article
    ID code:45073
    Notes:© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Keywords:biocatalysis, co-assembly, peptides, surface functionality, transformation, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Faculty of Science > Physics
    Technology and Innovation Centre > Bionanotechnology
    Depositing user: Pure Administrator
    Date deposited:08 Oct 2013 09:06
    Last modified:22 Jan 2020 17:11
    URI:https://strathprints.strath.ac.uk/id/eprint/45073
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