Resistance by allostery: a novel perspective for Eg5-targeted drug design

Viswanath, AN and Pae, AN and MacKay, Simon (2013) Resistance by allostery: a novel perspective for Eg5-targeted drug design. Journal of Medicinal Chemistry. ISSN 0022-2623 (https://doi.org/10.1021/jm401071u)

Abstract

Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.

ORCID iDs

MacKay, Simon ORCID: https://orcid.org/0000-0001-8000-6557

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  Item type:	Article
  ID code:	44509
  Dates:	Date Event 2013 Published
  Notes:	The reference referred to in the abstract has been selected for 'article of the month' by the editor of the journal. This is a commentary on the importance of the original article to drug discovery.
  Subjects:	Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	21 Aug 2013 10:39
  Last modified:	11 Nov 2024 10:27
  Related URLs:	http://pubs.acs.org/doi/abs/10.1021/jm40...
  URI:	https://strathprints.strath.ac.uk/id/eprint/44509