Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

Parkinson, John A and Scott, Fraser J and Suckling, Colin J and Wilson, Gail (2013) Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences. MedChemComm, 4 (7). pp. 1105-1108. (https://doi.org/10.1039/C3MD00071K)

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Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

ORCID iDs

Parkinson, John A ORCID logoORCID: https://orcid.org/0000-0003-4270-6135, Scott, Fraser J ORCID logoORCID: https://orcid.org/0000-0003-0229-3698, Suckling, Colin J and Wilson, Gail;
CORE (COnnecting REpositories)