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Organobase-catalyzed amidation of esters with amino alcohols

Caldwell, Nicola and Jamieson, Craig and Simpson, Iain and Tuttle, Tell (2013) Organobase-catalyzed amidation of esters with amino alcohols. Organic Letters, 15 (10). pp. 2506-2509. ISSN 1523-7060

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A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.