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Improving the understanding of oligonucleotide–nanoparticle conjugates using DNA-binding fluorophores

Guerrini, Luca and Barrett, Lee and Dougan, Jennifer A. and Faulds, Karen and Graham, Duncan (2013) Improving the understanding of oligonucleotide–nanoparticle conjugates using DNA-binding fluorophores. Nanoscale, 5 (10). pp. 4166-4170. ISSN 2040-3372

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Abstract

A novel fluorescent-based method for characterisation of oligonucleotide-nanoparticle conjugates (ONPCs) is reported. We exploit the ability of the double-stranded DNA-binding dye, SYBR Green I, to develop a powerful analytical tool to investigate the melting properties and hybridisation behavior of ONPCs as well as their corresponding DNA-mediated assemblies.