Development of a solvent selection guide for aldehyde-based direct reductive amination processes

McGonagle, Fiona I. and MacMillan, Donna S. and Murray, Jane and Sneddon, Helen F. and Jamieson, Craig and Watson, Allan J. B. (2013) Development of a solvent selection guide for aldehyde-based direct reductive amination processes. Green Chemistry, 15 (5). pp. 1159-1165. ISSN 1463-9262

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Abstract

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.