Development of a solvent selection guide for aldehyde-based direct reductive amination processes

McGonagle, Fiona I. and MacMillan, Donna S. and Murray, Jane and Sneddon, Helen F. and Jamieson, Craig and Watson, Allan J. B. (2013) Development of a solvent selection guide for aldehyde-based direct reductive amination processes. Green Chemistry, 15 (5). pp. 1159-1165. ISSN 1463-9262 (https://doi.org/10.1039/c3gc40359a)

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Abstract

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

ORCID iDs

McGonagle, Fiona I., MacMillan, Donna S., Murray, Jane, Sneddon, Helen F., Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272 and Watson, Allan J. B.;
CORE (COnnecting REpositories)