Enzymatic optical resolution via acylation-hydrolysis on a solid support

Ulijn, R V and Bisek, N and Flitsch, S L (2003) Enzymatic optical resolution via acylation-hydrolysis on a solid support. Organic and Biomolecular Chemistry, 1 (4). pp. 621-622. ISSN 1477-0520

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Abstract

By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.