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A micropatterned hydrogel platform for chemical synthesis and biological analysis

Zourob, M and Gough, J E and Ulijn, R V (2006) A micropatterned hydrogel platform for chemical synthesis and biological analysis. Advanced Materials, 18 (5). pp. 655-659. ISSN 0935-9648

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Abstract

A polymer hydrogel platform for peptide arrays compatible both with solid-phase peptide synthesis (SPPS) conditions and the aqueous environment essential for biological assays is demonstrated. Micropatterning followed by multiple-step peptide synthesis in situ is followed by proof-of-concept on-chip biological assays involving cells and enzymes (see Figure and cover).