Resonance Raman scattering of catalytic beacons for DNA detection

McKeating, Kristy S. and Graham, Duncan and Faulds, Karen (2013) Resonance Raman scattering of catalytic beacons for DNA detection. Chemical Communications, 49 (31). pp. 3206-3208. ISSN 1359-7345

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Abstract

A novel method for analysing the catalytic action of a DNAzyme is reported. Resonance Raman scattering (RRS) is shown to successfully monitor the oxidation of two different peroxidase substrates and has been implemented in an assay for the detection of target DNA, providing a more sensitive method of analysis than current colorimetric techniques.