Confined compression of collagen hydrogels
Busby, Grahame A. and Grant, M. Helen and MacKay, Simon P. and Riches, Philip E. (2013) Confined compression of collagen hydrogels. Journal of Biomechanics, 46 (4). pp. 837-840. ISSN 0021-9290 (https://doi.org/10.1016/j.jbiomech.2012.11.048)
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Abstract
Reconstituted collagen hydrogels are often used for in vitro studies of cell-matrix interaction and as scaffolds for tissue engineering. Understanding the mechanical and transport behaviours of collagen hydrogels is therefore extremely important, albeit difficult due to their very high water content (typically > 99.5%). In the present study the mechanical behaviour of collagen hydrogels in confined compression was investigated using biphasic theory (J. Biomech. Eng. 102 (1980) 73), to ascertain whether the technique is sufficiently sensitive to determine differences in the characteristics of hydrogels of between 0.2% and 0.4% collagen. Peak stress, equilibrium stress, aggregate modulus and hydraulic permeability of the hydrogels exhibited sensitivity to collagen content, demonstrating that the technique is clearly able to discriminate between hydrogels with small differences in collagen content and may also be sensitive to factors that affect matrix remodelling. The results also offer additional insight into the deformation-dependent permeability of collagen hydrogels. This study suggests that confined compression, together with biphasic theory, is a suitable technique for assessing the mechanical properties of collagen hydrogels.
ORCID iDs
Busby, Grahame A., Grant, M. Helen ORCID: https://orcid.org/0000-0002-7712-404X, MacKay, Simon P. ORCID: https://orcid.org/0000-0001-8000-6557 and Riches, Philip E. ORCID: https://orcid.org/0000-0002-7708-4607;-
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Item type: Article ID code: 42224 Dates: DateEvent22 February 2013Published23 December 2012Published OnlineSubjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering Department: Faculty of Engineering > Biomedical Engineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical SciencesDepositing user: Pure Administrator Date deposited: 28 Nov 2012 16:20 Last modified: 11 Nov 2024 10:13 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/42224