Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ

Reagan, Michaela R and Seib, F Philipp and McMillin, Douglas W and Sage, Elizabeth K and Mitsiades, Constantine S and Janes, Sam M and Ghobrial, Irene M and Kaplan, David L (2012) Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ. Journal of breast cancer, 15 (3). pp. 273-282. (https://doi.org/10.4048/jbc.2012.15.3.273)

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Abstract

Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.

ORCID iDs

Reagan, Michaela R, Seib, F Philipp ORCID logoORCID: https://orcid.org/0000-0002-1955-1975, McMillin, Douglas W, Sage, Elizabeth K, Mitsiades, Constantine S, Janes, Sam M, Ghobrial, Irene M and Kaplan, David L;
CORE (COnnecting REpositories)