Negishi coupling of metallated difluoroenol derivatives based on trifluoroethanol
Wilson, Peter and Percy, Jonathan M. and Redmond, Joanna M. (2011) Negishi coupling of metallated difluoroenol derivatives based on trifluoroethanol. Abstracts of papers - American Chemical Society, 242. FLUO-65.
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Difluorovinylmetal building blocks prepd. from 1-(2'-methoxy-ethoxymethoxy) -2,2,2-trifluoroethane (1a) and 1-(N,N-diethylcarbamoyloxy)-2,2,2-trifluoroethane (1b), have been used in our lab. in syntheses of analogs of biol. significant compds. Access to these useful reagents requires a dehydrofluorination/metalation step at -78°C; however, the seminal work of Donald Burton and co-workers have allowed us to prep. difluorovinylzinc reagents 2a and 2b and iodides 3a and 3b at near ambient temp. and investigate their scope in palladium catalyzed coupling.
ORCID iDs
Wilson, Peter, Percy, Jonathan M. ORCID: https://orcid.org/0000-0001-8636-2704 and Redmond, Joanna M.;-
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Item type: Article ID code: 42037 Dates: DateEvent28 August 2011PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 14 Nov 2012 13:55 Last modified: 11 Nov 2024 10:17 URI: https://strathprints.strath.ac.uk/id/eprint/42037