Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy

McCluskey, A. G. and Mairs, R. J. and Robson, T. and Hirst, D. G. and Boyd, M. (2012) Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy. Mutagenesis, 27 (1). p. 131. 82. ISSN 0267-8357 (https://doi.org/10.1093/mutage/ger068)

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Abstract

Radiotherapy given in combination with gene transfer is a promising approach for the treatment of cancer. However, progress in this field depends upon achieving the selective expression of therapeutic transgenes in tumours. Therefore, radiation-inducible gene promoters have attracted interest because they may enable temporal and spatial gene activation.

ORCID iDs

McCluskey, A. G. ORCID logoORCID: https://orcid.org/0000-0002-2249-1854, Mairs, R. J., Robson, T., Hirst, D. G. and Boyd, M. ORCID logoORCID: https://orcid.org/0000-0003-4120-2218;
CORE (COnnecting REpositories)