Mitochondrial organization and Ca2+ uptake

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Olson, Marnie L and Chalmers, Susan and McCarron, John G (2012) Mitochondrial organization and Ca2+ uptake. Biochemical Society Transactions, 40 (1). pp. 158-167. (https://doi.org/10.1042/BST20110705)

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Abstract

Mitochondria may function as multiple separate organelles or as a single electrically coupled continuum to modulate changes in [Ca2+]c (cytoplasmic Ca2+ concentration) in various cell types. Mitochondria may also be tethered to the internal Ca2+ store or plasma membrane in particular parts of cells to facilitate the organelles modulation of local and global [Ca2+]c increases. Differences in the organization and positioning contributes significantly to the at times apparently contradictory reports on the way mitochondria modulate [Ca2+]c signals. In the present paper, we review the organization of mitochondria and the organelles role in Ca2+ signalling.

ORCID iDs

Olson, Marnie L, Chalmers, Susan ORCID logoORCID: https://orcid.org/0000-0002-8073-7576 and McCarron, John G ORCID logoORCID: https://orcid.org/0000-0002-3302-3984;
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