Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

Parkinson, J.A. and Muller, P. and Shroder, B. and Kratochwil, N.A. and Coxall, R.A. and Parkin, A. and Parsons, S. and Sadler, P.J. (2003) Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes. Angewandte Chemie, 42 (3). pp. 335-339.

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Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.