Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis

Hay, J. and Graham, D.I. and Hutchison, W.M. and Siim, J.C. (1985) Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis. Annals of Tropical Medicine and Parasitology, 79 (1). pp. 21-29. ISSN 0003-4983

Abstract

A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.

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• Item metadata

  Item type:	Article
  ID code:	38105
  Dates:	Date Event 1985 Published
  Keywords:	meningo-encephalitis, retinochoroiditis, murine model, congenital toxoplasmosis, mice, brains, Chemistry, Infectious Diseases, Parasitology, SDG 3 - Good Health and Well-being
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	02 Mar 2012 13:38
  Last modified:	20 May 2023 03:32
  Related URLs:	Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/38105