Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis
Hay, J. and Graham, D.I. and Hutchison, W.M. and Siim, J.C. (1985) Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis. Annals of Tropical Medicine and Parasitology, 79 (1). pp. 21-29. ISSN 0003-4983
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A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
| Author(s): | Hay, J., Graham, D.I., Hutchison, W.M. and Siim, J.C. | Item type: | Article |
|---|---|
| ID code: | 38105 |
| Keywords: | meningo-encephalitis, retinochoroiditis, murine model, congenital toxoplasmosis, mice, brains, Chemistry, Infectious Diseases, Parasitology |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry |
| Depositing user: | Pure Administrator |
| Date deposited: | 02 Mar 2012 13:38 |
| Last modified: | 25 Jan 2019 03:11 |
| Related URLs: | |
| URI: | https://strathprints.strath.ac.uk/id/eprint/38105 |
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