Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis

Hay, J. and Graham, D.I. and Hutchison, W.M. and Siim, J.C. (1985) Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis. Annals of Tropical Medicine and Parasitology, 79 (1). pp. 21-29. ISSN 0003-4983

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Abstract

A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.