Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis
Hay, J. and Graham, D.I. and Hutchison, W.M. and Siim, J.C. (1985) Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis. Annals of Tropical Medicine and Parasitology, 79 (1). pp. 21-29. ISSN 0003-4983
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A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
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Item type: Article ID code: 38105 Dates: DateEvent1985PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 02 Mar 2012 13:38 Last modified: 08 Apr 2024 17:18 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/38105