Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction

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Chappelle, Michael R. and Morgan, Alan D. and Tomkinson, Nicholas C. O. and Willson, Timothy M.; Pleiss, Ulrich and Voges, R., eds. (2001) Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction. In: Synthesis and applications of isotopically labelled compounds, volume 7. Wiley-Blackwell, pp. 80-83. ISBN 0471495018

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Abstract

H-T exchange on 4,3,5-HO(Me3C)2C6H2CHO in presence of Crabtree's catalyst gave exclusively 4,3,5-HO(Me3C)2C6H2CTO, which was treated with CH2[P(O)(OEt)2]2 to give 4,3,5-HO(Me3C)2C6H2CT:CH[P(O)(OEt)2]2. The absence of ring tritiation in 4,3,5-HO(Me3C)2C6H2CHO is attributed to steric hindrance by the tert.-Bu groups. [on SciFinder(R)]

ORCID iDs

Chappelle, Michael R., Morgan, Alan D., Tomkinson, Nicholas C. O. ORCID logoORCID: https://orcid.org/0000-0002-5509-0133 and Willson, Timothy M.; Pleiss, Ulrich and Voges, R.
  • Item type:Book Section
    ID code:36062
    Dates:
    Date
    Event
    30 January 2001
    Published
    Notes:CAPLUS AN 2002:174743(Conference) 2nd ISBn print: 9780471495017
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:21 Nov 2011 16:37
    Last modified:11 Nov 2024 14:46
    URI:https://strathprints.strath.ac.uk/id/eprint/36062
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