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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle

Mccarron, John and Bradley, Karen and Macmillan, Debbi and Chalmers, Susan and Muir, Thomas C. (2004) The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle. News in Physiological Sciences, 19. pp. 138-147. ISSN 0886-1714

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Abstract

The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.

Author(s):Mccarron, John, Bradley, Karen, Macmillan, Debbi, Chalmers, Susan and Muir, Thomas C.
Item type:Article
ID code:36041
Keywords:inositol 1,4,5-trisphosphate receptors, cells, oscillations, induced calcium-release, Pharmacy and materia medica, Physiology
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Physiology and Pharmacology
Depositing user: Pure Administrator
Date deposited:18 Nov 2011 16:54
Last modified:03 Jan 2019 13:06
URI:https://strathprints.strath.ac.uk/id/eprint/36041
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