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The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

Colahan, P T and Savage, K A and Tebbett, I R and Rice, B L and Jackson, C A and Freshwater, L (2006) The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses. Equine veterinary journal, 38 (S36). pp. 262-266.

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Abstract

Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species.