Post-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide

Clegg, W and Dale, S H and Harrington, R W and Hevia, E and Honeyman, G W and Mulvey, R E (2006) Post-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide. Angewandte Chemie, 45 (15). pp. 2374-2377. ISSN 0044-8249 (https://doi.org/10.1002/anie.200503213)

Abstract

Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.

ORCID iDs

Hevia, E ORCID: https://orcid.org/0000-0002-3998-7506

Mulvey, R E ORCID: https://orcid.org/0000-0002-1015-2564

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  Item type:	Article
  ID code:	34750
  Dates:	Date Event 2006 Published
  Keywords:	alkali metals, amides, directing groups, metalation, zinc, zinc exchange-reaction, lithiation, reagents, reactivities, alkyl, Chemistry, Medicine(all)
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	21 Oct 2011 11:33
  Last modified:	02 Dec 2022 01:32
  URI:	https://strathprints.strath.ac.uk/id/eprint/34750