Post-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide

Clegg, W and Dale, S H and Harrington, R W and Hevia, E and Honeyman, G W and Mulvey, R E (2006) Post-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide. Angewandte Chemie, 45 (15). pp. 2374-2377. ISSN 0044-8249 (https://doi.org/10.1002/anie.200503213)

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Abstract

Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.

ORCID iDs

Clegg, W, Dale, S H, Harrington, R W, Hevia, E ORCID logoORCID: https://orcid.org/0000-0002-3998-7506, Honeyman, G W and Mulvey, R E ORCID logoORCID: https://orcid.org/0000-0002-1015-2564;
  • Item type:Article
    ID code:34750
    Dates:
    Date
    Event
    2006
    Published
    Keywords:alkali metals, amides, directing groups, metalation, zinc, zinc exchange-reaction, lithiation, reagents, reactivities, alkyl, Chemistry, Medicine(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:21 Oct 2011 11:33
    Last modified:03 Feb 2023 10:13
    URI:https://strathprints.strath.ac.uk/id/eprint/34750
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