Palladium catalyzed N-arylation of hydroxylamines

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Porzelle, Achim and Tomkinson, Nicholas C. O. (2009) Palladium catalyzed N-arylation of hydroxylamines. In: UNSPECIFIED.

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Abstract

Over the past decade modified Ullmann couplings and palladium-catalyzed arylations of nitrogen contg. compds. (Buchwald-Hartwig aminations) have emerged as powerful tools in synthetic chem. Interestingly, despite their biol. and synthetic significance, only three reports of cross couplings of hydroxylamines have been disclosed. This lack of investigation is surprising as N-aryl hydroxylamines are valuable intermediates in the prepn. of important nitrogen heterocycles including indoles, isoxazolidines oxadiazolidinones and aziridines. Within the poster we present a mild and efficient palladium catalyzed method for the prepn. of N-aryl hydroxylamines. The scope and limitations of the procedure will be detailed and methods for the selective deprotection of both the N- and O-functionality described allowing full advantage of this important functional group to be revealed.

ORCID iDs

Porzelle, Achim and Tomkinson, Nicholas C. O. ORCID logoORCID: https://orcid.org/0000-0002-5509-0133;
  • Item type:Conference or Workshop Item(Other)
    ID code:34163
    Dates:
    Date
    Event
    2009
    Published
    Notes:CAPLUS AN 2009:985378 (Conference; Meeting Abstract; Computer Optical Disk)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:11 Nov 2011 16:04
    Last modified:11 Nov 2024 16:31
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/34163
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