Palladium catalyzed N-arylation of hydroxylamines

Porzelle, Achim and Tomkinson, Nicholas C. O. (2009) Palladium catalyzed N-arylation of hydroxylamines. In: UNSPECIFIED.

Abstract

Over the past decade modified Ullmann couplings and palladium-catalyzed arylations of nitrogen contg. compds. (Buchwald-Hartwig aminations) have emerged as powerful tools in synthetic chem. Interestingly, despite their biol. and synthetic significance, only three reports of cross couplings of hydroxylamines have been disclosed. This lack of investigation is surprising as N-aryl hydroxylamines are valuable intermediates in the prepn. of important nitrogen heterocycles including indoles, isoxazolidines oxadiazolidinones and aziridines. Within the poster we present a mild and efficient palladium catalyzed method for the prepn. of N-aryl hydroxylamines. The scope and limitations of the procedure will be detailed and methods for the selective deprotection of both the N- and O-functionality described allowing full advantage of this important functional group to be revealed.

ORCID iDs

Tomkinson, Nicholas C. O. ORCID: https://orcid.org/0000-0002-5509-0133

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• Item metadata

  Item type:	Conference or Workshop Item(Other)
  ID code:	34163
  Dates:	Date Event 2009 Published
  Notes:	CAPLUS AN 2009:985378 (Conference; Meeting Abstract; Computer Optical Disk)
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	11 Nov 2011 16:04
  Last modified:	11 Nov 2024 16:31
  Related URLs:	Event
  URI:	https://strathprints.strath.ac.uk/id/eprint/34163