Bioaffinity detection of pathogens on surfaces
Wark, Alastair and Lee, J. and Kim, S. and Faisal, S. N. and Lee, H. J. (2010) Bioaffinity detection of pathogens on surfaces. Journal of Industrial and Engineering Chemistry, 16. pp. 169-177. ISSN 1226-086X (https://doi.org/10.1016/j.jiec.2010.01.061)
Preview |
PDF.
Filename: Wark_JIEC_2010_final.pdf
Preprint Download (992kB)| Preview |
Abstract
The demand for improved technologies capable of rapidly detecting pathogens with high sensitivity and selectivity in complex environments continues to be a significant challenge that helps drive the development of new analytical techniques. Surface-based detection platforms are particularly attractive as multiple bioaffinity interactions between different targets and corresponding probe molecules can be monitored simultaneously in a single measurement. Furthermore, the possibilities for developing new signal transduction mechanisms alongside novel signal amplification strategies aremuchmore varied. In this article, we describe some of the latest advances in the use of surface bioaffinity detection of pathogens. Three major sections will be discussed: (i) a brief overview on the choice of probe molecules such as antibodies, proteins and aptamers specific to pathogens and surface attachment chemistries to immobilize those probes onto various substrates, (ii) highlighting examples among the current generation of surface biosensors, and (iii) exploring emerging technologies that are highly promising and likely to form the basis of the next generation of pathogenic sensors.
ORCID iDs
Wark, Alastair ORCID: https://orcid.org/0000-0001-8736-7566, Lee, J., Kim, S., Faisal, S. N. and Lee, H. J.;-
-
Item type: Article ID code: 34124 Dates: DateEventJanuary 2010PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 11 Nov 2011 15:57 Last modified: 11 Sep 2024 00:36 URI: https://strathprints.strath.ac.uk/id/eprint/34124