Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging - the next dimension
Stone, Nicholas and Kerssens, Marleen and Lloyd, Gavin Rhys and Faulds, Karen and Graham, Duncan and Matousek, Pavel (2011) Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging - the next dimension. Chemical Science, 2 (4). pp. 776-780. ISSN 2041-6539 (https://doi.org/10.1039/c0sc00570c)
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SESORS - Surface enhanced spatially offset Raman spectroscopy-imaging is explored for the first time in this study. Multiplexed surface enhanced Raman scattering (SERS) signals have been recovered non-invasively from a depth of 20 mm in tissues for the first time and reconstructed to produce a false colour image. Four unique 'flavours' of SERS nanoparticles (NPs) were injected into a 20 x 50 x 50 mm porcine tissue block at the corners of a 10 mm square. A transmission Raman data cube was acquired over an 11 x 11 pixel grid made up of 2 mm steps. The signals were reconstructed using the unique peak intensities of each of the nanoparticles. A false colour image of the relative signal levels was produced, demonstrating the capability of multiplexed imaging of SERS nanoparticles using deep Raman spectroscopy. A secondary but no less significant achievement was to demonstrate that Raman signals from SERS nanoparticles can be recovered non-invasively from samples of the order of 45-50 mm thick. This is a significant step forward in the ability to detect and identify vibrational fingerprints within tissue and offers the opportunity to adapt these particles and this approach into a clinical setting for disease diagnosis.
ORCID iDs
Stone, Nicholas, Kerssens, Marleen, Lloyd, Gavin Rhys, Faulds, Karen ORCID: https://orcid.org/0000-0002-5567-7399, Graham, Duncan ORCID: https://orcid.org/0000-0002-6079-2105 and Matousek, Pavel;-
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Item type: Article ID code: 33654 Dates: DateEvent2011Published7 January 2011Published OnlineSubjects: Science > Chemistry > Physical and theoretical chemistry Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 17 Oct 2011 13:45 Last modified: 11 Nov 2024 09:50 URI: https://strathprints.strath.ac.uk/id/eprint/33654