DNA detection using enzymatic signal production and SERS

Dougan, Jennifer A. and MacRae, Douglas and Graham, Duncan and Faulds, Karen (2011) DNA detection using enzymatic signal production and SERS. Chemical Communications (London), 47 (16). pp. 4649-4651. ISSN 0009-241X

Abstract

A novel DNA assay is demonstrated which relies on the production of a surface enhanced resonance Raman scattering (SERS) signal following sequence specific hybridisation and enzyme hydrolysis. This method achieves high sensitivity and specificity that can be applied to the detection of unlabelled duplex DNA and is the first step towards a SERS based signal amplification approach.

ORCID iDs

Graham, Duncan ORCID: https://orcid.org/0000-0002-6079-2105

Faulds, Karen ORCID: https://orcid.org/0000-0002-5567-7399

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  Item type:	Article
  ID code:	33652
  Dates:	Date Event 2011 Published 15 March 2011 Published Online
  Keywords:	resonance ram-scattering, exonuclease, nanoparticles, fluorescence, lambda, TIC - Bionanotechnology, Physical and theoretical chemistry, Chemistry(all)
  Subjects:	Science > Chemistry > Physical and theoretical chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Bionanotechnology
  Depositing user:	Pure Administrator
  Date deposited:	17 Oct 2011 13:42
  Last modified:	19 Mar 2021 03:25
  URI:	https://strathprints.strath.ac.uk/id/eprint/33652