Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms : out of the shadow?
Pyne, Nigel J and Pyne, Susan (2011) Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms : out of the shadow? Trends in Pharmacological Sciences, 32 (8). pp. 443-450. (https://doi.org/10.1016/j.tips.2011.04.002)
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Receptor tyrosine kinases (RTKs) and G-protein-coupled receptors (GPCRs) can form platforms in which protein signalling components specific for each receptor are shared (owing to close proximity) to produce an integrated response upon engagement of ligands. RTK-GPCR signalling platforms respond to growth factors and GPCR agonists to increase gain over and above that which is normally produced by separate receptors. They can also function to change the spatial context of signalling in response to growth factor activation. The function of RTK-GPCR signalling platforms can be modulated with conformational-specific inhibitors that stabilise defined GPCR states to abrogate both GPCR agonist- and growth factor-stimulated cell responses. In this paper, we provide an opinion of the biology and unusual pharmacology of RTK-GPCR signalling platforms and make comparisons with a more traditional model of crosstalk between RTKs and GPCRs.
ORCID iDs
Pyne, Nigel J ORCID: https://orcid.org/0000-0002-5657-4578 and Pyne, Susan ORCID: https://orcid.org/0000-0002-6608-9584;-
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Item type: Article ID code: 32347 Dates: DateEventAugust 2011PublishedNotes: Copyright © 2011 Elsevier Ltd. All rights reserved. Subjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 28 Jul 2011 15:35 Last modified: 11 Nov 2024 09:48 URI: https://strathprints.strath.ac.uk/id/eprint/32347