Selectivity and specificity of sphingosine 1-phosphate receptor ligands : "off-targets" or complex pharmacology?
Pyne, Nigel J. and Pyne, Susan (2011) Selectivity and specificity of sphingosine 1-phosphate receptor ligands : "off-targets" or complex pharmacology? Frontiers in Pharmacology, 2. 26. (https://doi.org/10.3389/fphar.2011.00026)
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Abstract
A recent perspective published in Frontiers of Pharmacology by Salomone and Waeber (2011) discussed the selectivity and specificity of sphingosine 1-phosphate (S1P) receptor ligands. This perspective surveyed the use of various S1P receptor ligands and attempted to reconcile a number of inconsistencies in the predicted biological outcomes: these were interpreted as "off-target" effects. Therefore the perspective cautioned against the use of these S1P receptor ligands. Here we highlight the complex pharmacology of S1P receptors, which along with "inside-out" signaling might provide an alternative explanation for "off-target" effects.
ORCID iDs
Pyne, Nigel J. ORCID: https://orcid.org/0000-0002-5657-4578 and Pyne, Susan ORCID: https://orcid.org/0000-0002-6608-9584;-
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Item type: Article ID code: 32346 Dates: DateEvent31 May 2011PublishedSubjects: Medicine > Therapeutics. Pharmacology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 28 Jul 2011 15:41 Last modified: 11 Nov 2024 09:48 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/32346