Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase
Berdyshev, Evgeny V and Gorshkova, Irina and Usatyuk, Peter and Kalari, Satish and Zhao, Yutong and Pyne, Nigel J and Pyne, Susan and Sabbadini, Roger A and Garcia, Joe G.N. and Natarajan, Viswanathan (2011) Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase. PLoS One, 6 (1). e16571. (https://doi.org/10.1371/journal.pone.0016571)
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Abstract
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility.
ORCID iDs
Berdyshev, Evgeny V, Gorshkova, Irina, Usatyuk, Peter, Kalari, Satish, Zhao, Yutong, Pyne, Nigel J ORCID: https://orcid.org/0000-0002-5657-4578, Pyne, Susan ORCID: https://orcid.org/0000-0002-6608-9584, Sabbadini, Roger A, Garcia, Joe G.N. and Natarajan, Viswanathan;-
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Item type: Article ID code: 32345 Dates: DateEvent31 January 2011PublishedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 28 Jul 2011 15:32 Last modified: 11 Nov 2024 09:48 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/32345