In vitro variability in propofol absorption by different membrane oxygenators
Hickey, S. and Quasim, I. and Gaylor, J.D. (2001) In vitro variability in propofol absorption by different membrane oxygenators. In: 18th Spring Meeting of the Association of Cardiothoracic Anaesthetists, 2001-06-22.
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Meeting abstract focusing on the sequestration of drugs, such as fentanyl [1,2], thiopental, nitroglycerine and propofol [3] in the extracorporeal circuit in vitro. This phenomenon can change the pharmacokinetic behaviour of drugs during cardiopulmonary bypass, thus potentially leading to problems in achieving adequate dosing regimens. The aim of this in vitro laboratory study was to compare the binding of propofol to different oxygenator membranes, and to examine the effects of the type of prime solution and temperature on the rate of binding. The SM-35 membrane bound significantly more propofol than the membranes from the CML and the SAFE II. Binding of propofol in diluted blood was significantly less than in crystalloid solution. Temperature had little effect on propofol binding in either prime solution type.
| Author(s): | Hickey, S., Quasim, I. and Gaylor, J.D. | Item type: | Conference or Workshop Item(Other) |
|---|---|
| ID code: | 3134 |
| Keywords: | in vitro variability, drugs, bioscience, physiology, bioengineering, Medicine (General), Physiology |
| Subjects: | Medicine > Medicine (General) Science > Physiology |
| Department: | Faculty of Engineering > Bioengineering |
| Depositing user: | Strathprints Administrator |
| Date deposited: | 17 Apr 2007 |
| Last modified: | 23 Jan 2020 03:42 |
| Related URLs: | |
| URI: | https://strathprints.strath.ac.uk/id/eprint/3134 |
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