Thioctic acid modification of oligonucleotides using an H-phosphonate

Dougan, Jennifer A. and Reid, Andrew K. and Graham, Duncan (2010) Thioctic acid modification of oligonucleotides using an H-phosphonate. Tetrahedron Letters, 51 (44). pp. 5787-5790. ISSN 0040-4039 (https://doi.org/10.1016/j.tetlet.2010.08.107)

Abstract

The H-phosphonate of a derivative of thioctic acid (TA) was synthesized and used to introduce a disulfide moiety at the 5'-end of oligonucleotides. This method overcomes the difficulties experienced with the phosphoramidite approach when employing a cyclic disulfide in the starting alcohol. The disulfide-modified oligonucleotides are subsequently used in metallic nanoparticle (Au and Ag) and surface functionalisation for sensitive, sequence specific analytical detection strategies.

ORCID iDs

Graham, Duncan ORCID: https://orcid.org/0000-0002-6079-2105

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• Item metadata

  Item type:	Article
  ID code:	28671
  Dates:	Date Event 3 November 2010 Published
  Subjects:	Science > Science (General) Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Mrs Gillian Neeson
  Date deposited:	15 Nov 2010 10:08
  Last modified:	11 Nov 2024 09:38
  Related URLs:	Scopus publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/28671