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Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry

Brown, Sarah D. and Graham, Duncan (2010) Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry. Tetrahedron Letters, 51 (38). pp. 5032-5034. ISSN 0040-4039

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Abstract

Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell penetrating peptide. Here we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.